In the pursuit of advancing skincare formulations, researchers from Chiang Mai University in Thailand have set a new benchmark by successfully encapsulating the rejuvenating essence of Centella asiatica into liposomal preparations. This breakthrough work has been published in the “Journal of Liposome Research” and provides a comprehensive analysis of how this dermal targeting system may enhance the delivery of the plant’s potent compounds into the skin.
DOI: 10.1080/08982104.2019.1614952
The study by Wichayapreechar, Panikchar, Anuchapreeda, Songyot, Phongpradist, Rungsinee, Rungseevijitprapa, Wandee, and Ampasavate, Chadarat, reveals exciting prospects for the use of liposome technology to bolster the bioavailability of Centella asiatica extracts, which is steeped with triterpenes known for their healing and regenerative properties.
The Magical Herb: Centella Asiatica
Centella asiatica, commonly known as Gotu Kola, is a perennial herb native to the wetlands of Asia. Revered for centuries in folk medicine for its extensive medicinal properties, modern science has affirmed its ability to accelerate wound healing, improve skin elasticity, and fortify the skin barrier. This is largely credited to the triterpenoids such as asiaticoside, that are found within the plant.
Liposomes: Tiny Carriers with Great Potential
Liposomes are tiny vesicles made of lipid bilayers that can encapsulate active ingredients, protecting them from degradation and allowing for targeted delivery into the skin’s deeper layers. This characteristic makes liposomes an excellent medium for transporting the therapeutic agents found in Centella asiatica extract.
The Pursuit of Enhanced Dermal Absorption
The collaborative effort between the departments of Pharmaceutical Sciences, Clinical Microscopy, and Pharmaceutical Chemistry and Technology at Chiang Mai University sought to address a common challenge in dermatological treatment: improving the delivery of active compounds into the skin. The researchers focused on developing a system to enhance the permeation of asiaticoside via the skin barrier, hoping to harness its potential for cosmetic and therapeutic applications more effectively.
The Study: A Deep Dive into Skin Permeation
A comprehensive laboratory investigation was conducted, with formulations being tested for their physicochemical properties, particle size, surface morphology, and stability. Furthermore, the research team assessed the liposomes’ ability to penetrate the skin using a porcine skin model – an accepted analogue for human skin in permeation studies.
The findings were promising. The liposome formulations not only showed stability and favorable physicochemical characteristics but also demonstrated an increased ability to deliver asiaticoside through the skin layers. The researchers went further to optimize the liposomes by incorporating hyaluronic acid, another skin-beneficial ingredient, which enhanced the penetration abilities of the liposomes.
The Implications for Skincare and Beyond
This novel approach to deliver Centella asiatica extract opens doors to a range of applications. By improving the bioavailability of asiaticoside, these liposomal preparations could significantly enhance the efficacy of anti-aging, wound-healing, and skin-repair treatments. With the potential to revolutionize the way botanical extracts are utilized in skincare, the findings from this research could lead to the development of advanced topical applications that deliver results like never before.
References
1. Wichayapreechar, Panikchar et al. “Dermal targeting of Centella asiatica.” Journal of Liposome Research, 30(2):197-207, June 2020. DOI: 10.1080/08982104.2019.1614952
2. Bylka, Wiesława, et al. “Centella asiatica in cosmetology.” Postepy Dermatologii i Alergologii, 30(1): 46-49, Feb 2013.
3. Paocharoen, V. “The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients.” Journal of the Medical Association of Thailand, 93(Supplement 7): S166-S170, Dec 2010.
4. Honeywell-Nguyen, P. L., & Bouwstra, J. A. “Vesicles as a tool for transdermal and dermal delivery.” Drug Discovery Today: Technologies, 2(1): 67-74, 2005.
5. Menon, Govindarajan Krishna, et al. “A review on the cosmeceutical and external applications of Centella asiatica.” International Journal of Green Pharmacy, S46-S49, 2012.
Keywords
1. Centella Asiatica Skincare
2. Liposomal Delivery System
3. Triterpenoids in Skincare
4. Transdermal Plant Extracts
5. Asiaticoside Skin Benefits
In conclusion, the groundbreaking work featured in “Journal of Liposome Research” not only opens new avenues for enhancing the skin’s natural healing processes but also paves the way for future skincare innovations. The potential of liposomal encapsulated Centella asiatica extract to significantly upgrade skincare regimens is just beginning to be tapped, and this research promises exciting developments on the horizon for both the beauty industry and therapeutic dermatology.